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The U.S. Food and Drug Administration has approved Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) as treatment selection for chronic weight reduction in addition to a reduced-calorie diet and exercising.

Using two separate drugs to shed weight can be very effective you can find combinations as you're watching FDA now awaiting approval. When dealing with weight reduction and the those who go through it you ought to err on the side of caution and allow the FDA do its job and demand some study be done so your public knows the side effects and risks of the medications before we take them. Keep in mind that drug companies are in business to earn money and that they would say anything to keep people on the medications.

Researchers discovered that participants investing in this drug for a year, lost weight within 4 weeks and have kept the load off through the 56 weeks of the study. Contrave is really a combination with the drugs naltrexone and bupropion, which appears to reflect a whole new trend of weight-loss drugs that are made up of multiple active ingredient, that might make them far better and safer.

Combo-pilling will be the newest fad or better yet the newest to come under scrutiny and so it is just more publicly known recently, comb-pilling to lose weight has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular may be the fact that by right now there are not any long term prescription weightloss pills that have been authorized by the FDA besides orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications even though some of the combinations are already rejected or have yet to be approved by the FDA.

Seizures certainly are a side effect with Contrave and shouldn't be taken in those with seizure disorders. The drug could also raise hypertension and heart rate, and shouldn't be used in people with a history of heart attack or stroke in the last six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with all the drug.

The FDA also warned that Contrave can raise blood pressure levels and heartbeat and must stop used in patients with uncontrolled high hypertension, along with by anyone with heart-related and cerebrovascular (circulation system dysfunction impacting the mind) disease. Patients which has a history of cardiac arrest or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes which has a boxed warning to alert medical researchers and patients for the increased probability of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for smoking cessation.


The most common side effects reported with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.